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Patients who were responders during a 10-week double-blind phase with immediate-release paroxetine and during a 3-month double-blind extension phase were randomized to either immediate-release paroxetine or placebo in a 3-month double-blind relapse prevention phase.
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A study of outpatients with mdd who had responded to paroxetine hdrs total score 8 during an initial 8-week open treatment phase and were then randomized to continuation on paroxetine or placebo for 1 year demonstrated a significantly lower relapse rate for patients taking paroxetine 15 compared to those on placebo 39 .
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in a study of elderly patients with major depressive disorder, 3 of 104 patients treated with paroxetine hydrochloride controlled-release tablets and none of 109 placebo patients experienced liver transaminase elevations of potential clinical concern.